Assays of cell viability/toxicity by XTT, release of LDH and similar indicators.
Internalization assays
Sample preparation, inclusion, section and staining for preclinical histology (paraffin and frozen samples) as well as anatomopathological evaluation.
Complete necropsy:
Product characterization studies, solubility and other properties studies; Inmunoassay techniques; Molecular biology techniques; Cell culture techniques; Flow cytometry; Safety studies: Nervous, cardiovascular and respiratory systems; Toxicology studies; PK/PD studies, Security testing of advanced therapies using small and large animals models.
Complete necropsy:
Spectral confocal module coupled to an inverted microscope (4 objectives: 10x, 20x, 40x and 63x) equipped with three channels of spectral detection, AOBS (“Acousto-optical beam splitter”) and resonant scanner system. Argón, He/Ne and UV lasers. Incubation cabin for cells, which allows tracking of real-time processes.
Temporarily OUT OF ORDERUse of the system . X-ray photoelectron spectroscopy to measure quantitative elemental composition of surfaces (%) (except H and He).
Use of the system to measure the thickness of layers, and the composition, porosity and roughness of materials on a surface.
Tests in real time to measure:
·· Molecule-molecule interactions: Protein-protein, Receptor-ligand, Antibody-antigen, Biomaterial-molecule interactions, Biomaterial-cell interactions.
·· Microbial growth.
·· Cell metabolism.
Experiments of stability, growth,
etc, perfusion and dilution
Surface analysis of organic and inorganic materials (mass spectrum), map of chemical elements present in the surface of the sample (image), profile analysis shows sample analysis in depth.
Magnetometry on nanoparticles in solid form, ultra thin films, powders, liquids and even slurries:
Measurements of magnetic properties of materials:
Geophysical Research:
Biomedical Research:
Measurement of the relaxation times in aqueous solutions and biological samples containing superparamagnetic nanoparticles as contrast agents for MR images. For T1 in the continuous range 10 kHz to 80MHz; for T2 in the range 10 MHz to 80MHz.
Characterization of contrast agents for MR imaging, ascertaining their relaxivity and the dominant effect.
NMR relaxometry technique is an important analytical tool for NMR research and material characterization in both industrial and academic environments and has been successfully applied in a wide range of fields:
– Pharmaceutical Applications:
– Polymers Applications:
– Oil, gas and petroleum applications:
